POS-800 DROXIDOPA FOR MANAGEMENT OF CHRONIC HYPOTENSION IN HAEMODIALYSIS
نویسندگان
چکیده
منابع مشابه
Droxidopa for neurogenic orthostatic hypotension
OBJECTIVE To determine whether droxidopa, an oral norepinephrine precursor, improves symptomatic neurogenic orthostatic hypotension (nOH). METHODS Patients with symptomatic nOH due to Parkinson disease, multiple system atrophy, pure autonomic failure, or nondiabetic autonomic neuropathy underwent open-label droxidopa dose optimization (100-600 mg 3 times daily), followed, in responders, by 7-...
متن کاملNeurogenic orthostatic hypotension – management update and role of droxidopa
Orthostatic hypotension (OH) is defined as a significant decrease in blood pressure (BP) during the first 3 minutes of standing or a head up on a tilt table. Symptoms of OH are highly variable, ranging from mild light-headedness to recurrent syncope. OH occurs due to dysfunction of one or more components of various complex mechanisms that interplay closely to maintain BP in a normal range durin...
متن کاملIntegrated analysis of droxidopa trials for neurogenic orthostatic hypotension
BACKGROUND Droxidopa, a prodrug of norepinephrine, was approved for treatment of neurogenic orthostatic hypotension (nOH) due to primary autonomic disorders based on 3 randomized double-blind studies. We performed safety and efficacy analyses of this pooled dataset (n = 460). METHODS Efficacy was assessed using Orthostatic Hypotension Questionnaire (OHQ) scores (composite and individual items...
متن کاملNeurogenic orthostatic hypotension in Parkinson’s disease: evaluation, management, and emerging role of droxidopa
Neurogenic orthostatic hypotension (nOH) is due to failure of the autonomic nervous system to regulate blood pressure in response to postural changes due to an inadequate release of norepinephrine, leading to orthostatic hypotension and supine hypertension. nOH is common in Parkinson's disease (PD). Prevalence varies throughout the course of PD, ranging from 40% to 60%, and resulting in symptom...
متن کاملNeurogenic orthostatic hypotension with critical illness neuropathy treated with droxidopa.
☆ Dr. Allen contributed to the drafting and editing; drafting and editing; Dr. Papadopoulos contributed to the contributed to the drafting, editing, and all final decisio interest; Dr. Charles has no conflict of interest; Dr. Pa interest; Dr. Avila has no conflict of interest.Funding: Non ⁎ Corresponding author at: Department of Neurology, M Center, 1275 York Avenue, New York, NY 10065, United ...
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ژورنال
عنوان ژورنال: Kidney International Reports
سال: 2021
ISSN: 2468-0249
DOI: 10.1016/j.ekir.2021.03.833